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Semaglutide commonly causes nausea, vomiting, and abdominal discomfort, while ibuprofen and other nonsteroidal anti-inflammatory drugs (NSAIDs) can irritate the stomach lining and increase the risk of gastric ulcers and bleeding

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Tirzepatide was associated with an increased thyroid cancer risk (reporting odds ratio [ROR] = 2.09, 95% CI: 1.512.89), though its risk was lower compared to other GLP-1 receptor agonists such as liraglutide (ROR = 15.59) and semaglutide (ROR = 7.61)